Anesthetic-induced Improvement of the Inflammatory Response to One-lung Ventilation

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Anesthetic-induced improvement of the inflammatory response to one-lung ventilation.

BACKGROUND Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess possible immunomodulatory effects of the anesthetics propofol and sevoflurane....

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Effects of propofol and desflurane anaesthesia on the alveolar inflammatory response to one-lung ventilation.

BACKGROUND One-lung ventilation (OLV) induces a pro-inflammatory response including cytokine release and leucocyte recruitment in the ventilated lung. Whether volatile or i.v. anaesthetics differentially modulate the alveolar inflammatory response to OLV is unclear. METHODS Thirty patients, ASA II or III, undergoing open thoracic surgery were randomized to receive either propofol 4 mg kg(-1) ...

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The application of the independent lung ventilation (ILV) in adults has been described by Carlon and co-workers in 1978 and subsequently by other investigators. In 1983 Hedenstierna and coworkers using a bilumen tube suitable for prolonged intubation, and two Servo Ventilator 900 B (Siemens) adapted for synchronization, treated a wide range of clinical conditions. Following this experience, the...

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The Effect of One Lung Ventilation on Intrapulmonary Shunt During Different Anesthetic Techniques

To facilitate the work of the thoracic surgeon it has become accepted procedure in certain circumstances to collapse the diseased lung being operated upon. To accomplish this, the technique most frequently used by the anaesthetist calls for the insertion of a double lumen endobronchial tube. This makes it possible to isolate the intact dependent lung from the diseased upper one and thus to prev...

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Maintaining adequate oxygenation during one-lung ventilation (OLV) requires high inspired oxygen fraction (FiO2). However, high FiO2 also causes inflammatory response and lung injury. Therefore, it remains a great interest to clinicians and scientists to optimize the care of patients undergoing OLV. The aim of this study was to determine and compare oxygenation, inflammatory response and lung i...

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ژورنال

عنوان ژورنال: Anesthesiology

سال: 2009

ISSN: 0003-3022

DOI: 10.1097/aln.0b013e3181a10731